Η ακρίβεια της μέτρησης ορμονικών υποδοχέων και HER2 με ανοικτή βιοψία και με βιοψία δια ευρύστομης βελόνας: Μία μετα -ανάλυση

Στο περιοδικό Breast Cancer Research and Treatment  στις 27/2/12, δημοσιεύθηκε μία μετανάλυση 27 μελετών που συνέκριναν την ακρίβεια στον προσδιορισμό των ορμονικών υποδοχέων και του HER2 μεταξύ της βιοψίας με ευρύστομη βελόνα ( βιοψία πυρήνα - Core Needle Biopsy) και της ανοικτής βιοψίας ( open excission biopsy). 
Η βιοψία με ευρύστομη βελόνα έχει υψηλή διαγνωστική ακρίβεια.
http://www.springerlink.com/content/fnt03081q4346946/
Πλήρη παρουσίαση των στοιχείων και της περίληψης της μελέτης:

Reference Type: Journal Article

Author: Chen, Xiaosong

Author: Yuan, Ying

Author: Gu, Zhaoxiang

Author: Shen, Kunwei

Primary Title: Accuracy of estrogen receptor, progesterone receptor, and HER2 status between core needle and open excision biopsy in breast cancer: a meta-analysis

Journal Name: Breast Cancer Research and Treatment

Publisher: Springer Netherlands

Issn: 0167-6806

Subject: Medicine

Start Page: 1

End Page: 11

Url: http://dx.doi.org/10.1007/s10549-012-1990-z

Doi: 10.1007/s10549-012-1990-z

Abstract: Accurate determination of estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor-2 (HER2) status was very important in selecting breast cancer treatment. Discordance of ER, PR, and HER2 status between core needle biopsy (CNB) and open excision biopsy (OEB) varied among reported studies. We performed a meta-analysis to compare the accuracy of CNB with that of OEB for ER, PgR, and HER2 status detection in breast cancer. Medical subject heading (MeSH) terms (Breast Neoplasm) and key words (biopsy OR mammotome) AND (incision OR excision OR surgery) AND (estrogen OR progesterone OR HER2 OR hormone). Patients with HER2 immunohistochemical 3+ or fluorescence in situ hybridization positive were classified into HER2[b] group. A total of 27 studies were eligible in this study. Aggregate positive ER and PgR rate was 80.0 and 69.5% for CNB; and 77.7 and 66.2% for OEB, respectively. The HER2 positive rate difference between CNB and OEB was only 0.2%. The pooled sensitivity of evaluating ER, PgR, and HER2 status in CNB compared with OEB was 0.970, 0.911, and 0.799 (0.813 for HER2[b]), respectively. All of AUC values for these status determination were larger than 0.9. Heterogeneity between studies was introduced by various factors in PgR and HER2[b] analysis. Subgroup analysis showed that the specificity and OR of CNB in studies with ER positive rate >78% was lower than studies with ER positive rate ≤78% ( P < 0.05). This meta-analysis indicated that CNB had high diagnostic accuracy in evaluating ER, PgR, and HER2 status compared with OBE in breast cancer patients. In terms of 2–3% positive rate difference, ER and PgR status should be detected both on CNB and OEB samples, especially to retest their expression on CNB in patients with hormonal receptor negative tumors in OEB.